The mammary gland bioreactor offers a highly efficient and economically feasible approach for large-scale production of recombinant proteins. In recent years, significant progress has been made in expressing diverse bioactive proteins within different animal mammary glands. CD BioSciences takes pride in introducing our service for the development of goat models with mammary gland bioreactors, aiming to leverage the unique advantages of goats in biopharmaceutical protein production.
Advantages of Goats for Mammary Bioreactors
Goats offer several distinct advantages as bioreactors for mammary gland production. Their moderate size, ease of handling, and relatively short gestation period make them an excellent choice for genetic modification and protein synthesis. Moreover, goats produce milk with a composition highly conducive to recombinant protein expression, closely resembling the structure and function of human proteins.
Fig.1 Cas9-mediated HNP1 knock-in in goats at the CSN2 locus. (Li, D., et al., 2024)
Our Services
Our comprehensive service for the development of mammary gland bioreactor goat models covers all aspects of model creation, ranging from initial design to protein extraction and characterization. We provide a wide range of tailored services to meet specific research and production needs.
Gene Editing Technologies
To achieve precise and efficient integration of foreign genes, we utilize a range of advanced gene editing technologies.
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| CRISPR/Cas9 Technology |
TALENs |
Cre-loxP Technology |
- Precise and efficient gene editing to integrate foreign genes into the goat genome.
- Ensuring specific expression in mammary glands for optimal protein production.
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- Customizable and highly specific gene editing to achieve targeted gene insertion.
- Enhancing the stability and expression levels of recombinant proteins.
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- Utilizing the Cre-loxP recombination system to achieve precise and conditional gene modifications.
- Allowing for controlled gene expression and functional studies in mammary glands.
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Model Establishment Methods
To create transgenic goat models, we employ various model establishment methods that ensure high efficiency and stable protein expression.
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| Somatic Cell Nuclear Transfer (SCNT) |
Pronuclear Microinjection |
Embryonic Stem Cell Modification |
- Cloning goats by transferring the nucleus of a genetically modified somatic cell into an enucleated oocyte.
- Producing transgenic goats with high consistency and stable protein expression.
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- Direct injection of foreign DNA into the pronuclei of fertilized goat eggs.
- Rapid generation of transgenic goats expressing recombinant proteins.
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- Editing genes in embryonic stem cells before integrating them into goat embryos.
- Producing goats with desired genetic modifications and stable protein expression.
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Contact Us
CD BioSciences' mammary gland bioreactor goat model development service offers a revolutionary approach to biopharmaceutical protein production. By leveraging the unique advantages of goat models, we provide a scalable, efficient, and cost-effective solution for generating high-quality recombinant proteins. For more information or to discuss how we can assist with your specific requirements, please feel free to contact us. Together, we can drive your biopharmaceutical production to new heights.
Reference
- Li, D., et al.; (2024). Genetically Engineered Goats as Efficient Mammary Gland Bioreactors for Production of Recombinant Human Neutrophil Peptide 1 Using CRISPR/Cas9. Biology, 13(6), 367.
Our services are for research use only and cannot be used for any clinical purposes.
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