The utilization of transgenic animals as bioreactors for the synthesis and secretion of recombinant proteins in milk is currently a prevailing trend in the advancement of biotechnologies. Recent advancements in genetic engineering, particularly the emergence of targeted genome editing technologies, have presented novel opportunities and significantly enhanced efficiency in generating animals capable of producing economically important recombinant proteins within their milk.
Advantages of Mammary Gland Bioreactor
The core of the animal mammary gland bioreactor lies in the efficient and specific expression of foreign genes driven by tissue-specific promoters within the mammary gland, resulting in the production of target products in milk. In comparison to other pharmaceutical methods, this approach offers several advantages.
- Enhanced Activity of Recombinant Proteins
Animal mammary glands can perform various post-processing modifications such as glycosylation, lipidation, phosphorylation, and carboxylation on expressed proteins, resulting in products that closely resemble natural extracts.
- Increased Production Yield of Therapeutic Proteins
The mammary gland has the capacity to express foreign genes at levels ranging from a few grams to tens of grams per liter.
- Reduced Production Costs
A genetically modified animal serves as a pharmaceutical factory with the ability for infinite multiplication, facilitating scale-up production with low feeding expenses; most costs are associated with product purification.
- Absence of Environmental Pollution
The mammary gland bioreactor industry essentially operates within an animal husbandry framework without releasing toxic or harmful substances during product purification processes.
- Minimal Impact on Animals' Well-being
As an exocrine gland, only minimal amounts of foreign proteins enter the circulatory system through the mammary gland's secretion pathway, thereby avoiding potential harm caused by excessive exogenous protein exposure to animal health.
- Reduced Marketing Cycle of New Drugs
The utilization of mammary gland reactors for the production of novel protein drugs will result in a reduction of approximately 10 years in the development timeline.
Our Services
CD BioSciences offers comprehensive mammary gland bioreactor genetic engineering services designed to optimize and enhance the expression of recombinant proteins in mammary glands. Leveraging advanced genetic engineering tools and techniques, we address the complexities of foreign gene integration, regulatory sequence optimization, and protein expression stability.
Gene Editing Technologies
Our gene editing services utilize cutting-edge technologies to introduce specific genetic modifications in mammary gland cells.
Mammary Gland Bioreactor CRISPR/Cas9 Service
Our CRISPR/Cas9 service employs a highly precise gene-editing tool to target and modify specific genomic sequences in mammary gland. This technology allows for high specificity and efficiency, ensuring stable integration and expression of recombinant proteins.
Mammary Gland Bioreactor TALENs Service
The TALENs service utilizes transcription activator-like effector nucleases to create specific double-strand breaks in the DNA. This approach facilitates targeted gene integration with minimal off-target effects, ensuring reliable and consistent protein production.
Mammary Gland Bioreactor Cre-loxP Service
Our Cre-loxP service provides a versatile system for site-specific recombination in mammary gland cells. This technique is ideal for conditional gene expression and precise genetic modifications, enabling controlled and high-quality protein production.
Development of Genetically Engineered Animals
Our model development services create transgenic animal models with mammary glands engineered to produce recombinant proteins.
Mammary Gland Bioreactor Models
Contact Us
At CD BioSciences, we are committed to providing comprehensive and innovative solutions for mammary gland bioreactor genetic engineering. Contact us today to learn more about how our services can support your research and development goals.
Our services are for research use only and cannot be used for any clinical purposes.
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